1105 In a mouse model of glioblastoma, treatment with VEGF-C increases lymphatic drainage in the central nervous system and improves the immune response, suggesting that modulating meningeal lymphatics could enhance checkpoint inhibitor therapy.
https://www.nature.com/articles/s41586-019-1912-x
1104 An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors.
https://science.sciencemag.org/content/367/6476/446
1103 High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.
https://www.pnas.org/content/117/3/1666
1102 Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth.
https://advances.sciencemag.org/content/6/3/eaay2174
1101 Oncolytic vaccinia virus encoding IL-7 and IL-12 facilitates immune checkpoint blockade in treatment-resistant solid tumors.
https://stm.sciencemag.org/content/12/526/eaax7992
1100 Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.
https://stm.sciencemag.org/content/12/526/eaax9340
1099 Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer.
https://www.pnas.org/content/early/2019/12/26/1904022116
1098 HBO1 is required for the maintenance of leukaemia stem cells.
https://www.nature.com/articles/s41586-019-1835-6
1097 An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors.
https://science.sciencemag.org/content/early/2019/12/30/science.aay5967
1096 Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer.
https://stm.sciencemag.org/content/12/524/eaax7533
1095 An artificial intelligence (AI) system performs as well as or better than radiologists at detecting breast cancer from mammograms, and using a combination of AI and human inputs could help to improve screening efficiency.
https://www.nature.com/articles/s41586-019-1799-6
1094 IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.
https://rupress.org/jcb/article-abstract/219/2/e201903017/133547/IPO11-mediates-catenin-nuclear-import-in-a-subset?redirectedFrom=fulltext
1093 Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus.
https://www.pnas.org/content/116/52/26909
1092 Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.
https://www.pnas.org/content/116/52/26580
1091 Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body.
https://www.cell.com/cell/fulltext/S0092-8674(19)31269-3
1090 The GLASS Consortium studies the evolutionary trajectories of 222 patients with a diffuse glioma to aid in our understanding of tumour progression and treatment failure.
https://www.nature.com/articles/s41586-019-1775-1
1089 Imaging and sequencing approaches are combined to show that extrachromosomal DNA (ecDNA) in cancer is circular and has unique chromatin structure that amplifies oncogene output.
https://www.nature.com/articles/s41586-019-1763-5
1088 Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.
https://science.sciencemag.org/content/366/6468/1029
1087 Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation.
https://www.nature.com/articles/s43018-019-0004-z
1086 Immunity to commensal papillomaviruses protects against skin cancer.
https://www.nature.com/articles/s41586-019-1719-9
|
