1177 Expression of the axon-guidance gene Slit2 in endothelium, induced by endothelial sensing of tumour-derived double-stranded RNA, promotes metastatic dissemination in mouse models of breast and lung cancer.
https://www.nature.com/articles/s41586-020-2774-y
1176 The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.
https://www.nature.com/articles/s41586-020-2541-0
1175 B cell acute lymphoblastic leukemia cells mediate RANK-RANKL–dependent bone destruction.
https://stm.sciencemag.org/content/12/561/eaba5942
1174 Interleukin-2 signals converge in a lymphoid–dendritic cell pathway that promotes anticancer immunity.
https://stm.sciencemag.org/content/12/561/eaba5464
1173 The bacterial-derived metabolite inosine enhances cancer immunotherapy in mice.
https://science.sciencemag.org/content/369/6510/1481
1172 Ageing in humans is associated with an increase in circulating methylmalonic acid, which induces expression of SOX4 and promotes tumour progression.
https://www.nature.com/articles/s41586-020-2630-0
1171 An effective combination immunotherapy using oncolytic viruses delivers de novo CD19 to promote CD19-CAR T cell therapy against solid tumors in mice.
https://stm.sciencemag.org/content/12/559/eaaz1863
1170 Lymph protects metastasizing melanoma cells from ferroptosis.
https://www.nature.com/articles/s41586-020-2623-z
1169 An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma.
https://www.nature.com/articles/s41586-020-2537-9
1168 Combination of BET inhibitor and vinorelbine improves survival in preclinical models of brain metastases.
https://stm.sciencemag.org/content/12/558/eaax2879
1167 Discovery and molecular pharmacology of non-nucleotide STING agonists that induce “closed” STING conformation and antitumor immunity are described.
https://science.sciencemag.org/content/369/6506/eaba6098
1166 A cancer evaluation criterion based on T cell receptors is potentially useful for noninvasive early cancer detection.
https://stm.sciencemag.org/content/12/557/eaaz3738
1165 CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis.
https://stm.sciencemag.org/content/12/555/eaaz9746
1164 Phosphoprotein-based biomarkers as predictors for cancer therapy.
https://www.pnas.org/content/117/31/18401
1163 The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma.
https://stm.sciencemag.org/content/12/554/eaaz3339
1162 In vivo anticancer activity of a rhodium metalloinsertor in the HCT116 xenograft tumor model.
https://www.pnas.org/content/117/30/17535
1161 Tumor cell lysate-loaded immunostimulatory spherical nucleic acids as therapeutics for triple-negative breast cancer.
https://www.pnas.org/content/117/30/17543
1160 An engineered version of IL-18 that is resistant to binding by the soluble decoy receptor IL-18BP shows strong anti-tumour activity in mouse models of cancer.
https://www.nature.com/articles/s41586-020-2422-6
1159 Fasting-mimicking diet and hormone therapy induce breast cancer regression.
https://www.nature.com/articles/s41586-020-2502-7
1158 An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth.
https://www.pnas.org/content/117/29/16938
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