1205 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
https://www.pnas.org/content/118/13/e2015433118
1204 A role for keratin 17 during DNA damage response and tumor initiation.
https://www.pnas.org/content/118/13/e2020150118
1203 T cells engineered with synthetic receptors that integrate components of T cell and B cell receptors show efficacy against solid tumors in mice.
https://stm.sciencemag.org/content/13/586/eabb5191
1202 TCR β chain–directed bispecific antibodies for the treatment of T cell cancers.
https://stm.sciencemag.org/content/13/584/eabd3595
1201 RNA interference–based spherical nucleic acid nanoconjugates are a potentially safe and brain-penetrant approach for glioblastoma treatment.
https://stm.sciencemag.org/content/13/584/eabb3945
1200 Identification of a metabolic checkpoint involving lipid signalling that is specific to regulatory T cells (Treg cells) in the tumour microenvironment raises the possibility of targeting this checkpoint for treatment of cancer.
https://www.nature.com/articles/s41586-021-03235-6
1199 In mouse models of pancreatic cancer, a cooperative interaction between tissue damage and Kras gene mutation rapidly induces cancer-associated chromatin states in pre-malignant tissue, leading to gene dysregulation and neoplastic transformation.
https://www.nature.com/articles/s41586-020-03147-x
1198 Fragmentation patterns of cell-free DNA from urine differ between healthy individuals and those with cancer.
https://stm.sciencemag.org/content/13/581/eaaz3088
1197 Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles.
https://www.pnas.org/content/118/7/e2020575118
1196 Percutaneous liquid ablation agent for tumor treatment and drug delivery.
https://stm.sciencemag.org/content/13/580/eabe3889
1195 Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling.
https://www.pnas.org/content/118/6/e2005191118
1194 Resistance to immunotherapy can be overcome using fecal microbiota transplantation for patients with metastatic melanoma.
https://science.sciencemag.org/content/371/6529/602
1193 Expression of the Epstein–Barr virus protein LMP1 in B cells increases expression of—and promotes T cell responses to—tumour-associated antigens, delineating a mechanism of infection-induced anti-tumour immunity, which could inform immune-based approaches to cancer treatment.
https://www.nature.com/articles/s41586-020-03075-w
1192 Efficient detection and post-surgical monitoring of colon cancer with a multi-marker DNA methylation liquid biopsy.
https://www.pnas.org/content/118/5/e2017421118
1191 Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin.
https://www.pnas.org/content/118/5/e2020478118
1190 ACE2 is protective against renal cancer, and its down-modulation by inhibitors of VEGF receptor signaling may mediate resistance to such inhibitors.
https://stm.sciencemag.org/content/13/577/eabc0170
1189 Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer.
https://stm.sciencemag.org/content/13/575/eaba6110
1188 Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
https://www.cell.com/cell/fulltext/S0092-8674(20)31526-9
1187 Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
https://www.nature.com/articles/s41586-020-2911-7
1186 The dose threshold for nanoparticle tumour delivery.
https://www.nature.com/articles/s41563-020-0755-z
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