1217 Positron emission tomography measurements of nutrient uptake in cells of the tumour microenvironment reveal cell-intrinsic partitioning in which glucose uptake is higher in myeloid cells, whereas glutamine is preferentially acquired by cancer cells.
https://www.nature.com/articles/s41586-021-03442-1
1216 Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
https://www.pnas.org/content/118/19/e2020490118
1215 Platinum(II) N-heterocyclic carbene complexes arrest metastatic tumor growth.
https://www.pnas.org/content/118/17/e2025806118
1214 Combining IL-15 superagonist and anti-GITR agonist therapy enhances antitumor effects of radiation therapy in a mouse model of mesothelioma.
https://stm.sciencemag.org/content/13/589/eabd9882
1213 A phase 1 clinical trial provides evidence that a vaccine against mutant IDH1 is safe and produces a T helper immune response in patients with glioma.
https://www.nature.com/articles/s41586-021-03363-z
1212 Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma.
https://www.pnas.org/content/118/15/e2013598118
1211 Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.
https://www.nature.com/articles/s41556-021-00644-7
1210 Mitochondrial copper depletion suppresses triple-negative breast cancer in mice.
https://www.nature.com/articles/s41587-020-0707-9
1209 Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression.
https://stke.sciencemag.org/content/14/677/eaax5971
1208 Breast tumours maintain a reservoir of subclonal diversity during expansion.
https://www.nature.com/articles/s41586-021-03357-x
1207 Acute myeloid leukemia cells are dependent on the DNA repair function of valosin-containing protein, opening up an avenue for disease treatment.
https://stm.sciencemag.org/content/13/587/eabg1168
1206 Identification of bacteria-derived HLA-bound peptides in melanoma.
https://www.nature.com/articles/s41586-021-03368-8
1205 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
https://www.pnas.org/content/118/13/e2015433118
1204 A role for keratin 17 during DNA damage response and tumor initiation.
https://www.pnas.org/content/118/13/e2020150118
1203 T cells engineered with synthetic receptors that integrate components of T cell and B cell receptors show efficacy against solid tumors in mice.
https://stm.sciencemag.org/content/13/586/eabb5191
1202 TCR β chain–directed bispecific antibodies for the treatment of T cell cancers.
https://stm.sciencemag.org/content/13/584/eabd3595
1201 RNA interference–based spherical nucleic acid nanoconjugates are a potentially safe and brain-penetrant approach for glioblastoma treatment.
https://stm.sciencemag.org/content/13/584/eabb3945
1200 Identification of a metabolic checkpoint involving lipid signalling that is specific to regulatory T cells (Treg cells) in the tumour microenvironment raises the possibility of targeting this checkpoint for treatment of cancer.
https://www.nature.com/articles/s41586-021-03235-6
1199 In mouse models of pancreatic cancer, a cooperative interaction between tissue damage and Kras gene mutation rapidly induces cancer-associated chromatin states in pre-malignant tissue, leading to gene dysregulation and neoplastic transformation.
https://www.nature.com/articles/s41586-020-03147-x
1198 Fragmentation patterns of cell-free DNA from urine differ between healthy individuals and those with cancer.
https://stm.sciencemag.org/content/13/581/eaaz3088
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