38 In vivo silencing in specific cell types remains the main obstacle for therapeutic applications of siRNAs. Leuschner et al. now show that an optimized lipid nanoparticle delivers siRNA to inflammatory monocytes in mice and, when transporting CCR2 siRNA, has therapeutic effects in cardiovascular disease, cancer and transplant rejection.
http://www.nature.com/nbt/journal/v29/n11/abs/nbt.1989.html
37 Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe.
http://stm.sciencemag.org/content/3/110/110ra119.abstract
36 Large-scale production of functional human serum albumin from transgenic rice seeds.
http://www.pnas.org/content/108/47/19078.abstract
35 Efficient bacterial production of bioplastics.
http://www.pnas.org/content/108/47/18920
34 Functionalized arrays of Raman-enhancing nanoparticles for capture and culture-free analysis of bacteria in human blood.
http://www.nature.com/ncomms/journal/v2/n11/full/ncomms1546.html
33 Self-assembly of DNA nanotubes with controllable diameters.
http://www.nature.com/ncomms/journal/v2/n11/full/ncomms1535.html
32 Visualization of plasmid delivery to keratinocytes in mouse and human epidermis.
http://www.nature.com/srep/2011/111115/srep00158/full/srep00158.html
31 Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging.
http://www.pnas.org/content/108/46/18837.abstract
30 Structure-Based Vaccines Provide Protection in a Mouse Model of Ehrlichiosis. Thomas S., et al. (2011). PLoS One 6(11): e27981.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027981#cor1
29 Brakemann et al. present a reversibly photoswitchable fluorescent protein, called Dreiklang, that can be turned on and off at wavelengths distinct from those used for imaging. They show that the protein is advantageous for studying protein dynamics in living cells and for super-resolution imaging.
http://www.nature.com/nbt/journal/v29/n10/abs/nbt.1952.html
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