206 PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation.
http://stm.sciencemag.org/content/10/438/eaao0303
205 Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity.
http://science.sciencemag.org/content/360/6387/449
204 The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure.
https://www.nature.com/articles/s41467-017-02361-y
203 The biosynthesis of methanobactin.
http://science.sciencemag.org/content/359/6382/1411
202 The conserved long noncoding RNA MeXis has anti-atherosclerotic effects in mice by acting with the nuclear hormone receptor LXR in macrophages to promote cholesterol efflux.
https://www.nature.com/articles/nm.4479
201 Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions.
http://www.pnas.org/content/115/10/2461
200 Natural noncanonical protein splicing yields products with diverse β-amino acid residues.
http://science.sciencemag.org/content/359/6377/779
199 Reversibility of citrate synthase allows autotrophic growth of a thermophilic bacterium.
http://science.sciencemag.org/content/359/6375/563
198 Distinct roles of N- and O-glycans in cellulase activity and stability.
http://www.pnas.org/content/114/52/13667.abstract
197 Heterochiral peptide macrocycles have been designed de novo with high accuracy.
http://science.sciencemag.org/content/358/6369/1461
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