228 The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis.
https://www.nature.com/articles/s41586-019-0920-1
227 Using a make-on-demand library that contains hundreds-of-millions of molecules, structure-based docking was used to identify compounds that, after synthesis and testing, are shown to interact with AmpC β-lactamase and the D4 dopamine receptor with high affinity.
https://www.nature.com/articles/s41586-019-0917-9
226 Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
https://www.nature.com/articles/s41467-018-08008-w
225 Two-step pathway for isoprenoid synthesis.
https://www.pnas.org/content/116/2/506
224 Dietary sugar silences a colonization factor in a mammalian gut symbiont.
https://www.pnas.org/content/116/1/233
223 Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
https://www.nature.com/articles/s41586-018-0749-z
222 A metal-binding peptide becomes a potent catalyst for ester hydrolysis.
http://science.sciencemag.org/content/362/6420/1285
221 Mannose impairs tumour growth and enhances chemotherapy.
https://www.nature.com/articles/s41586-018-0729-3
220 A biomimetic receptor for glucose.
https://www.nature.com/articles/s41557-018-0155-z
219 Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model.
http://www.pnas.org/content/115/44/E10427
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