236 Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation.
https://www.pnas.org/content/116/12/5370
235 The integration of liver and plasma quantitative lipidomic and proteomic data from 107 distinct mouse strains provides important insights into regulators of mammalian lipid metabolism.
https://www.nature.com/articles/s41586-019-0984-y
234 LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism.
https://www.pnas.org/content/116/11/4940
233 A lipase-independent pathway of lipid release and immune modulation by adipocytes.
http://science.sciencemag.org/content/363/6430/989
232 The plasma membrane lipid sphingomyelin has two distinct conformations depending on the presence or absence of cholesterol.
https://www.cell.com/cell/fulltext/S0092-8674(18)31656-8
231 The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species.
https://www.nature.com/articles/s41467-019-08555-w
230 Redox and pH gradients drive amino acid synthesis in iron oxyhydroxide mineral systems.
https://www.pnas.org/content/early/2019/02/19/1812098116
229 Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
https://www.nature.com/articles/s41586-019-0904-1
228 The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis.
https://www.nature.com/articles/s41586-019-0920-1
227 Using a make-on-demand library that contains hundreds-of-millions of molecules, structure-based docking was used to identify compounds that, after synthesis and testing, are shown to interact with AmpC β-lactamase and the D4 dopamine receptor with high affinity.
https://www.nature.com/articles/s41586-019-0917-9
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