253 Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome.

252 Targeting cartilage EGFR pathway for osteoarthritis treatment

251 Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties.

250 A deltamethrin crystal polymorph for more effective malaria control.

249 Designed miniproteins bind tightly to the SARS-CoV-2 spike protein and prevent binding to the host cell receptor.

248 Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

247 Modular synthesis and structural biology are used to design and characterize group A streptogramin antibiotics, one of which has activity against streptogramin-resistant strains and demonstrates efficacy in a mouse model of bacterial infection.

246 Biosynthesis of medicinal tropane alkaloids in yeast.

245 Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.

244 Discovery and engineering of colchicine alkaloid biosynthesis.

243 Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics.

242 Monomeric insulin stabilized with polymeric excipient exhibits increased stability and faster pharmacokinetics than current rapid-acting insulins.

241 Galidesivir, a broad-spectrum direct-acting adenosine analog antiviral drug, abrogates viremia in rhesus macaques infected with Zika virus.

240 Structures of mycobacterial glycosyltransferases define a binding site for an anti-tuberculosis drug.

239 An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells.

238 Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.

237 Elesclomol therapy stops the progression of neurodegeneration and improves survival in a mouse model of Menkes disease.

236 An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.

235 An open-source drug discovery platform enables ultra-large virtual screens.

234 A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination.

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