273 A high-throughput virtual screen followed by experimental testing generates therapeutic leads for non-opioid pain killers.

272 Tirzepatide Once Weekly for the Treatment of Obesity.

271 Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.

270 Computer-designed repurposing of chemical wastes into drugs.

269 Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring.

268 Two Phase 3 Trials of Baricitinib for Alopecia Areata.

267 Bacterioboat is a good bacteria-based oral drug delivery tool that enhances drug efficacy and potency and makes drugs safer.

266 Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria.

265 An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.

264 Rational design of a new antibiotic class for drug-resistant infections.

263 A repurposing screen identifies the orally available drug masitinib as able to inhibit virus replication in mouse-based models of COVID-19.

262 The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.

261 Inhalable nanocatchers for SARS-CoV-2 inhibition.

260 The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase.

259 Neutralization of endothelial lipase with a monoclonal antibody raises functional HDL in both nonhuman primates and in healthy humans.

258 Neoadjuvant treatment with nivolumab plus ipilimumab is well tolerated and demonstrates clinical efficacy in patients with early stage lung cancer.

257 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.

256 The clinically approved drugs ticagrelor and oseltamivir fortify a pathway of platelet-mediated immunity to clear staphylococcal bacteremia in mice.

255 Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.

254 Bepridil is potent against SARS-CoV-2 in vitro.

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