155 An orally active small molecule, AdipRon, that binds to and activates both adiponectin receptors (AdipoR1 and AdipoR2) is identified; it ameliorates diabetes in mice on a high-fat diet and in genetically obese db/db mice, and if this can be extrapolated to humans, orally active agonists such as AdipoRon are a promising new approach to treat obesity-related diseases such as type 2 diabetes.
http://www.nature.com/nature/journal/v503/n7477/full/nature12656.html
154 The activity of a specific metabolite of cholesterol may help explain why obesity is a risk factor for breast cancer.
http://www.sciencemag.org/content/342/6162/1094.abstract
153 Association of Nut Consumption with Total and Cause-Specific Mortality.
http://www.nejm.org/doi/full/10.1056/NEJMoa1307352
152 Long-term treatment of obese, insulin-resistant nonhuman primates with a seed-targeting antimiR oligonucleotide against the microRNA-33 family derepresses hepatic expression of miR-33 targets, increases circulating HDL cholesterol, and has a clean safety profile.
http://stm.sciencemag.org/content/5/212/212ra162.abstract
151 Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.
http://www.nature.com/nchembio/journal/v9/n11/abs/nchembio.1352.html
150 Dietary Behaviour and Socioeconomic Position: The Role of Physical Activity Patterns.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0078390
149 A neural circuit from the parabrachial nucleus to the central nucleus of the amygdala mediates appetite suppression.
http://www.nature.com/nature/journal/v503/n7474/full/nature12596.html
148 Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00372-0
147 Semaphorin3E-Induced Inflammation Contributes to Insulin Resistance in Dietary Obesity.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00369-0
146 Fat-overloaded hepatocytes release microparticles that induce angiogenesis and worsening of fatty liver disease.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/296/ra88
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