Cancer Biology

1223 A nanovaccine based on bacterial cytoplasmic membranes and cell membranes from resected tumor tissue prevents tumor recurrence in mice.

1222 Down-regulation of A20 promotes immune escape of lung adenocarcinomas.

1221 Initiation and progression of leukemogenesis in Down syndrome involves distinct cellular origins and effects of trisomy 21.

1220 Li et al. identify LIMIT as a lncRNA that modulates MHC-I expression through HSP90 and HSF1, thereby regulating antitumour immune response and the efficacy of immunotherapy.

1219 AI-based pathology predicts origins for cancers of unknown primary.

1218 Treatment with a specific inhibitor of the N6-methyladenosine methyltransferase METTL3 leads to reduced growth of cancer cells, indicating the potential of approaches targeting RNA-modifying enzymes for anticancer therapy.

1217 Positron emission tomography measurements of nutrient uptake in cells of the tumour microenvironment reveal cell-intrinsic partitioning in which glucose uptake is higher in myeloid cells, whereas glutamine is preferentially acquired by cancer cells.

1216 Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.

1215 Platinum(II) N-heterocyclic carbene complexes arrest metastatic tumor growth.

1214 Combining IL-15 superagonist and anti-GITR agonist therapy enhances antitumor effects of radiation therapy in a mouse model of mesothelioma.

1213 A phase 1 clinical trial provides evidence that a vaccine against mutant IDH1 is safe and produces a T helper immune response in patients with glioma.

1212 Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma.

1211 Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.

1210 Mitochondrial copper depletion suppresses triple-negative breast cancer in mice.

1209 Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression.

1208 Breast tumours maintain a reservoir of subclonal diversity during expansion.

1207 Acute myeloid leukemia cells are dependent on the DNA repair function of valosin-containing protein, opening up an avenue for disease treatment.

1206 Identification of bacteria-derived HLA-bound peptides in melanoma.

1205 A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.

1204 A role for keratin 17 during DNA damage response and tumor initiation.

Free Images for Presentation: sunipix SUNIPIX