Cancer Biology

 
1237 A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models.
https://www.science.org/doi/10.1126/scitranslmed.aba7791

1236 Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
https://www.cell.com/cell/fulltext/S0092-8674(21)00879-5

1235 METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
https://www.pnas.org/content/118/35/e2025948118

1234 Cycling cancer persister cells arise from lineages with distinct programs.
https://www.nature.com/articles/s41586-021-03796-6

1233 A new computational approach to in silico mutagenesis screening allow comprehensive mapping of cancer driver mutations.
https://www.nature.com/articles/s41586-021-03771-1

1232 Drivers and suppressors of triple-negative breast cancer.
https://www.pnas.org/content/118/33/e2104162118

1231 Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models.
https://stm.sciencemag.org/content/13/606/eabd1616

1230 UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.
https://www.pnas.org/content/118/31/e2103592118

1229 EGFR activation limits the response of liver cancer to lenvatinib.
https://www.nature.com/articles/s41586-021-03741-7

1228 A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
https://stm.sciencemag.org/content/13/603/eabf1383

1227 Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels.
https://www.pnas.org/content/118/29/e2023868118

1226 Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
https://stm.sciencemag.org/content/13/602/eaba4627

1225 Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade.
https://stm.sciencemag.org/content/13/602/eabb3631

1224 Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment.
https://www.pnas.org/content/118/28/e2101169118

1223 A nanovaccine based on bacterial cytoplasmic membranes and cell membranes from resected tumor tissue prevents tumor recurrence in mice.
https://stm.sciencemag.org/content/13/601/eabc2816

1222 Down-regulation of A20 promotes immune escape of lung adenocarcinomas.
https://stm.sciencemag.org/content/13/601/eabc3911

1221 Initiation and progression of leukemogenesis in Down syndrome involves distinct cellular origins and effects of trisomy 21.
https://science.sciencemag.org/content/373/6551/eabf6202

1220 Li et al. identify LIMIT as a lncRNA that modulates MHC-I expression through HSP90 and HSF1, thereby regulating antitumour immune response and the efficacy of immunotherapy.
https://www.nature.com/articles/s41556-021-00672-3

1219 AI-based pathology predicts origins for cancers of unknown primary.
https://www.nature.com/articles/s41586-021-03512-4

1218 Treatment with a specific inhibitor of the N6-methyladenosine methyltransferase METTL3 leads to reduced growth of cancer cells, indicating the potential of approaches targeting RNA-modifying enzymes for anticancer therapy.
https://www.nature.com/articles/s41586-021-03536-w

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