Medical Science

150 Factoring in new gene therapy treatments for hemophilia A.

149 Identification of acutely sick people and facial cues of sickness.

148 Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.

147 Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.

146 Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.

145 Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis.

144 Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del.

143 Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors.

142 Engineering a highly elastic human protein–based sealant for surgical applications.

141 Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia.

140 Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 (for organ transplant in humans).

139 Trial of Tocilizumab in Giant-Cell Arteritis.

138 High serum serotonin in sudden infant death syndrome.

137 Lithium Use in Pregnancy and the Risk of Cardiac Malformations.

136 Oral Glucocorticoid–Sparing Effect of Benralizumab in Severe Asthma.

135 Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling.

134 Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women.

133 Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015.

132 Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice.

131 Quarter-dose quadruple combination therapy for initial treatment of hypertension.

130 Gene Therapy in a Patient with Sickle Cell Disease.

129 Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis.

128 Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis.

127 Hand-powered ultralow-cost paper centrifuge.

126 SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways.

125 Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor.

124 A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers.

123 Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.

122 Reloadable multidrug capturing delivery system for targeted ischemic disease treatment.

121 An injectable shear-thinning biomaterial for endovascular embolization.

120 Interventions to prevent and reduce physician burnout: a systematic review and meta-analysis.

119 Calciprotein particles as potential etiologic agents of idiopathic preterm birth.

118 Purinergic receptors in the carotid body as a new drug target for controlling hypertension.

117 Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope.

116 Chronic Cough.

115 Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo.

114 Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome.

113 The economic burden of physical inactivity.

112 Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality?

111 Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents.

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