Medical Science

182 Personalized omics profiling can lead to actionable health discoveries and stimulate lifestyle changes.

181 Detecting middle ear fluid using smartphones.

180 Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients.

179 A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

178 A genome-wide polygenic score quantifies inherited susceptibility to obesity, integrating information from 2.1 million common genetic variants to identify adults at risk of severe obesity.

177 In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis.

176 Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care.

175 Physical exertion exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophy.

174 In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression.

173 Identifying facial phenotypes of genetic disorders using deep learning.

172 Roles of mucus adhesion and cohesion in cough clearance.

171 Birth delivery mode alters perinatal cell death in the mouse brain.

170 Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis.

169 Effect of Aspirin on Disability-free Survival in the Healthy Elderly.

168 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

167 Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis.

166 Use of Deep Learning to Examine the Association of the Built Environment With Prevalence of Neighborhood Adult Obesity.

165 Rheotaxis-based separation of sperm with progressive motility using a microfluidic corral system.

164 Targeted therapy in patients with PIK3CA-related overgrowth syndrome.

163 A Randomized Trial of Early Endovenous Ablation in Venous Ulceration.

162 Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.

161 Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma.

160 Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD.

159 Effect of antibiotic use for acute bronchiolitis on new-onset asthma in children.

158 Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.

157 Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations.

156 A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops.

155 Smartphone-based blood pressure monitoring via the oscillometric finger-pressing method.

154 Long-term effects of glucocorticoids on function, quality of life, and survival in patients with Duchenne muscular dystrophy: a prospective cohort study.

153 Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance.

152 Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing.

151 Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett’s esophagus.

150 Factoring in new gene therapy treatments for hemophilia A.

149 Identification of acutely sick people and facial cues of sickness.

148 Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.

147 Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.

146 Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.

145 Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis.

144 Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del.

143 Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors.

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