Medical Science

Articles:
168 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
https://www.nature.com/articles/s41588-018-0205-x#Abs1

167 Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis.
https://www.nejm.org/doi/full/10.1056/NEJMoa1803583

166 Use of Deep Learning to Examine the Association of the Built Environment With Prevalence of Neighborhood Adult Obesity.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2698635

165 Rheotaxis-based separation of sperm with progressive motility using a microfluidic corral system.
http://www.pnas.org/content/115/33/8272

164 Targeted therapy in patients with PIK3CA-related overgrowth syndrome.
https://www.nature.com/articles/s41586-018-0217-9

163 A Randomized Trial of Early Endovenous Ablation in Venous Ulceration.
https://www.nejm.org/doi/full/10.1056/NEJMoa1801214

162 Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.
https://www.nejm.org/doi/full/10.1056/NEJMoa1706314

161 Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma.
https://www.nejm.org/doi/full/10.1056/NEJMoa1715274

160 Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD.
https://www.nejm.org/doi/full/10.1056/NEJMoa1713901

159 Effect of antibiotic use for acute bronchiolitis on new-onset asthma in children.
https://www.nature.com/articles/s41598-018-24348-5

158 Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.
http://www.pnas.org/content/115/14/3686

157 Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations.
http://www.nejm.org/doi/full/10.1056/NEJMoa1714257

156 A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops.
http://www.nejm.org/doi/full/10.1056/NEJMoa1717250?query=featured_home

155 Smartphone-based blood pressure monitoring via the oscillometric finger-pressing method.
http://stm.sciencemag.org/content/10/431/eaap8674

154 Long-term effects of glucocorticoids on function, quality of life, and survival in patients with Duchenne muscular dystrophy: a prospective cohort study.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32160-8/fulltext

153 Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance.
http://stm.sciencemag.org/content/10/427/eaam8604

152 Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing.
http://advances.sciencemag.org/content/4/1/eaap9004

151 Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett’s esophagus.
http://stm.sciencemag.org/content/10/424/eaao5848

150 Factoring in new gene therapy treatments for hemophilia A.
http://stm.sciencemag.org/content/10/423/eaar7511

149 Identification of acutely sick people and facial cues of sickness.
http://rspb.royalsocietypublishing.org/content/285/1870/20172430

148 Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.
https://www.nature.com/articles/nature25164

147 Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.
http://stm.sciencemag.org/content/9/420/eaal3765

146 Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.
http://www.nejm.org/doi/full/10.1056/NEJMoa1708538

145 Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1709847

144 Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del.
http://www.nejm.org/doi/full/10.1056/NEJMoa1709846

143 Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors.
http://www.nejm.org/doi/full/10.1056/NEJMoa1615977?query=featured_home

142 Engineering a highly elastic human protein–based sealant for surgical applications.
http://stm.sciencemag.org/content/9/410/eaai7466

141 Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia.
http://www.nejm.org/doi/full/10.1056/NEJMoa1704559

140 Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 (for organ transplant in humans).
http://science.sciencemag.org/content/early/2017/08/09/science.aan4187

139 Trial of Tocilizumab in Giant-Cell Arteritis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1613849

138 High serum serotonin in sudden infant death syndrome.
http://www.pnas.org/content/114/29/7695.abstract

137 Lithium Use in Pregnancy and the Risk of Cardiac Malformations.
http://www.nejm.org/doi/full/10.1056/NEJMoa1612222

136 Oral Glucocorticoid–Sparing Effect of Benralizumab in Severe Asthma.
http://www.nejm.org/doi/full/10.1056/NEJMoa1703501

135 Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling.
http://science.sciencemag.org/content/356/6345/1352

134 Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women.
http://www.nejm.org/doi/full/10.1056/NEJMoa1612337

133 Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30260-X/fulltext

132 Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice.
http://stm.sciencemag.org/content/9/386/eaai9044

131 Quarter-dose quadruple combination therapy for initial treatment of hypertension.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30260-X/fulltext

130 Gene Therapy in a Patient with Sickle Cell Disease.
http://www.nejm.org/doi/full/10.1056/NEJMoa1609677

129 Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis.
http://www.nejm.org/doi/full/10.1056/NEJMoa1608345

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