Systems Biology

19 Affinity purification–mass spectrometry elucidates protein interaction networks and co-complexes to build, to our knowledge, the largest experimentally derived human protein interaction network so far, termed BioPlex 2.0.

18 Long-term neural and physiological phenotyping of a single human.

17 A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.

16 Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals “aging factors” and mechanism of lifespan asymmetry.

15 Automated identification of stratifying signatures in cellular subpopulations.

14 Identifying regulatory mechanisms underlying tumorigenesis using locus expression signature analysis.

13 Pulendran and colleagues use a systems biology analysis to reveal distinct transcriptional signatures of antibody responses to different classes of human vaccines.

12 Reconstruction of protein networks from an atlas of maize seed proteotypes.

11 Discovery of a kernel for controlling biomolecular regulatory networks.

10 Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimers Disease.

9 Pattern discovery and cancer gene identification in integrated cancer genomic data.

8 The protein expression landscape of the Arabidopsis root.

7 A Systems Biology Approach to Drug Targets in Pseudomonas aeruginosa Biofilm.

6 Systems Biology Approaches Reveal a Specific Interferon-Inducible Signature in HTLV-1 Associated Myelopathy.

5 A review of imaging techniques for systems biology.

4 Initial characterization of the human central proteome.

3 Identifying cancer biomarkers by network-constrained support vector machines.

2 Network analysis of microRNAs and their regulation in human ovarian cancer.

1 Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems.

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