Structural Biology

120 Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase.

119 X-ray structure of the human α4β2 nicotinic receptor.

118 Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs.

117 Structure of the STRA6 receptor for retinol uptake.

116 Structure of mammalian respiratory complex I.

115 Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.

114 Crystal structure of the epithelial calcium channel TRPV6.

113 Extra-helical binding site of a glucagon receptor antagonist.

112 The crystal structure of Cpf1 in complex with CRISPR RNA.

111 X-ray crystal structures of the human serotonin transporter (SERT) bound to the antidepressants (S)-citalopram or paroxetine show that the antidepressants lock the protein in an outward-open conformation, and directly block serotonin from entering its binding site; the structures define the mechanism of antidepressant action in SERT and pave the way for future drug design.

110 Reconstitution, spectroscopy, and crystallography allow the construction of a model of the human nuclear pore.

109 Observing cellulose biosynthesis and membrane translocation in crystallo.

108 Structure of transcribing mammalian RNA polymerase II.

107 X-ray crystal structures of two distinct steps in the catalytic cycle of non-ribosomal peptide synthetases are described, offering the potential to generate novel products through engineering enzyme activity.

106 Structure of the voltage-gated calcium channel Cav1.1 complex.

105 Architecture of the mammalian mechanosensitive Piezo1 channel.

104 Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.

103 Structure and mechanism of the mammalian fructose transporter GLUT5.

102 Crystal structures of a double-barrelled fluoride ion channel.

101 The structure of DNA by direct imaging.

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