Structural Biology

111 X-ray crystal structures of the human serotonin transporter (SERT) bound to the antidepressants (S)-citalopram or paroxetine show that the antidepressants lock the protein in an outward-open conformation, and directly block serotonin from entering its binding site; the structures define the mechanism of antidepressant action in SERT and pave the way for future drug design.

110 Reconstitution, spectroscopy, and crystallography allow the construction of a model of the human nuclear pore.

109 Observing cellulose biosynthesis and membrane translocation in crystallo.

108 Structure of transcribing mammalian RNA polymerase II.

107 X-ray crystal structures of two distinct steps in the catalytic cycle of non-ribosomal peptide synthetases are described, offering the potential to generate novel products through engineering enzyme activity.

106 Structure of the voltage-gated calcium channel Cav1.1 complex.

105 Architecture of the mammalian mechanosensitive Piezo1 channel.

104 Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.

103 Structure and mechanism of the mammalian fructose transporter GLUT5.

102 Crystal structures of a double-barrelled fluoride ion channel.

101 The structure of DNA by direct imaging.

100 Structure and mechanism of the ATPase that powers viral genome packaging.

99 Retroviruses such as HIV rely on the intasome, a tetramer of integrase protein bound to the viral DNA ends interacting with host chromatin, for integration into the host genome; the structure of the intasome as it interacts with a nucleosome is now solved, giving insight into the integration process.

98 Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.

97 Electron cryomicroscopy shows structures of three distinct rotational states of the V-ATPase from Saccharomyces cerevisiae.

96 Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography.

95 Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.

94 Structure of the human 80S ribosome.

93 Crystal structure of the eukaryotic origin recognition complex.

92 The structure of the ~400-kD coat nucleoporin complex of yeast is Y-shaped.

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