Structural Biology

127 The crystal structure of the bacterial potassium import complex KdpFABC shows how ATP hydrolysis is coupled to potassium transport to maintain cellular homeostasis under low potassium conditions.

126 Structure of the Human Lipid Exporter ABCA1.

125 Structure and function of the Zika virus full-length NS5 protein.

124 Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.

123 Crystal Structure of an LSD-Bound Human Serotonin Receptor.

122 Principles for designing proteins with cavities formed by curved β sheets.

121 Crystal structure of unlinked NS2B-NS3 protease from Zika virus.

120 Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase.

119 X-ray structure of the human α4β2 nicotinic receptor.

118 Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs.

117 Structure of the STRA6 receptor for retinol uptake.

116 Structure of mammalian respiratory complex I.

115 Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.

114 Crystal structure of the epithelial calcium channel TRPV6.

113 Extra-helical binding site of a glucagon receptor antagonist.

112 The crystal structure of Cpf1 in complex with CRISPR RNA.

111 X-ray crystal structures of the human serotonin transporter (SERT) bound to the antidepressants (S)-citalopram or paroxetine show that the antidepressants lock the protein in an outward-open conformation, and directly block serotonin from entering its binding site; the structures define the mechanism of antidepressant action in SERT and pave the way for future drug design.

110 Reconstitution, spectroscopy, and crystallography allow the construction of a model of the human nuclear pore.

109 Observing cellulose biosynthesis and membrane translocation in crystallo.

108 Structure of transcribing mammalian RNA polymerase II.

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