68 Structures of the acetohydroxyacid synthase complexes of Saccharomyces cerevisiae and Arabidopsis thaliana provide insights into the biosynthesis of and feedback inhibition by branched-chain amino acids.
https://www.nature.com/articles/s41586-020-2514-3
67 ROR2 blockade improves the functional and structural outcomes of osteoarthritis in preclinical animal models by inhibiting YAP signaling.
https://stm.sciencemag.org/content/12/561/eaax3063
66 In a mouse model of the leukodystrophy Pelizaeus–Merzbacher disease, myelination, motor performance, respiratory function and lifespan are improved by suppressing proteolipid protein expression, suggesting PLP1 as a therapeutic target for human patients with this disease and, more broadly, antisense oligonucleotides as a pharmaceutical modality for treatment of myelin disorders.
https://www.nature.com/articles/s41586-020-2494-3
65 An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.
https://www.pnas.org/content/117/31/18431
64 Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion.
https://www.pnas.org/content/117/27/15731
63 A conserved protein kinase VRK-1 increases life span by activating a key energy sensor AMPK in the roundworm C. elegans.
https://advances.sciencemag.org/content/6/27/eaaw7824
62 The proteome landscape of the kingdoms of life.
https://www.nature.com/articles/s41586-020-2402-x
61 A compound that disassembles the circadian repressive super-complex can reset circadian phase and relieve jet lag in mice.
https://stm.sciencemag.org/content/12/542/eaba0769
60 A human binary protein interactome map that includes around 53,000 protein–protein interactions involving more than 8,000 proteins provides a reference for the study of human cellular function in health and disease.
https://www.nature.com/articles/s41586-020-2188-x
59 FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.
https://www.pnas.org/content/117/6/3135
58 The enzymatic activity of caspase-8 controls apoptosis, necroptosis and pyroptosis, and prevents tissue damage during embryonic development and adulthood in mice.
https://www.nature.com/articles/s41586-019-1770-6
57 Correcting a protein network that regulates proteostasis reverses deficits in a mouse model of Down syndrome.
https://science.sciencemag.org/content/366/6467/843
56 An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
https://stm.sciencemag.org/content/11/517/eaaw1131
55 mTORC1 senses nutrient sufficiency by recognizing conformational changes in its lysosomal anchor, heterodimeric Rag GTPase.
https://science.sciencemag.org/content/366/6464/468
54 How internal cavities destabilize a protein.
https://www.pnas.org/content/116/42/21031
53 A membrane protein, Shisa7, regulates trafficking, kinetics, and pharmacology of GABAA receptors.
https://science.sciencemag.org/content/366/6462/246
52 YY1 transcriptionally represses TGFB1 in mice and may be a potential drug target for treating diabetic nephropathy.
https://stm.sciencemag.org/content/11/510/eaaw2050
51 A selective cell-penetrating scorpion toxin targets the irritant receptor, TRPA1, via a distinct biochemical mechanism from that used by irritants, allowing definition of a new mechanism of channel activation and interrogation of pathways of pain sensitization.
https://www.cell.com/cell/fulltext/S0092-8674(19)30779-2
50 LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis.
https://www.cell.com/cell/fulltext/S0092-8674(19)30786-X
49 The plasmodium protein kinase PfCLK3 provides a specific protein kinase target for antimalarial development.
https://science.sciencemag.org/content/365/6456/eaau1682
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