83 Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.
https://www.science.org/doi/10.1126/science.abe6723
82 Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202104581
81 Highly accurate protein structure prediction with AlphaFold.
https://www.nature.com/articles/s41586-021-03819-2
80 Highly accurate protein structure prediction for the human proteome.
https://www.nature.com/articles/s41586-021-03828-1
79 Protein structure modeling enables the rapid solution of protein structures and provides insights into function.
https://science.sciencemag.org/content/373/6557/871
78 Accurate prediction of protein structures and interactions using a three-track neural network.
https://science.sciencemag.org/content/early/2021/07/14/science.abj8754
77 Interferon-induced APOL3 is a detergent-like protein that kills cytosolic pathogens to protect human cells against infection.
https://science.sciencemag.org/content/373/6552/eabf8113
76 Data storage using peptide sequences.
https://www.nature.com/articles/s41467-021-24496-9
75 Computationally designed proteins assemble antibodies into precise and potent nanostructures.
https://science.sciencemag.org/content/372/6537/eabd9994
74 The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.
https://www.pnas.org/content/118/11/e2019251118
73 The intracellular environment affects protein–protein interactions.
https://www.pnas.org/content/118/11/e2019918118
72 A versatile platform reprograms botulinum neurotoxin proteases to selectively cleave proteins of biomedical interest in vitro and in neurons.
https://science.sciencemag.org/content/371/6531/803
71 Successful de novo design of transmembrane β-barrel proteins provides insight into the principles that guide their folding.
https://science.sciencemag.org/content/371/6531/eabc8182
70 DeepTFactor: A deep learning-based tool for the prediction of transcription factors.
https://www.pnas.org/content/118/2/e2021171118
69 The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease.
https://www.nature.com/articles/s41586-020-2681-2
68 Structures of the acetohydroxyacid synthase complexes of Saccharomyces cerevisiae and Arabidopsis thaliana provide insights into the biosynthesis of and feedback inhibition by branched-chain amino acids.
https://www.nature.com/articles/s41586-020-2514-3
67 ROR2 blockade improves the functional and structural outcomes of osteoarthritis in preclinical animal models by inhibiting YAP signaling.
https://stm.sciencemag.org/content/12/561/eaax3063
66 In a mouse model of the leukodystrophy Pelizaeus–Merzbacher disease, myelination, motor performance, respiratory function and lifespan are improved by suppressing proteolipid protein expression, suggesting PLP1 as a therapeutic target for human patients with this disease and, more broadly, antisense oligonucleotides as a pharmaceutical modality for treatment of myelin disorders.
https://www.nature.com/articles/s41586-020-2494-3
65 An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.
https://www.pnas.org/content/117/31/18431
64 Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion.
https://www.pnas.org/content/117/27/15731
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