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83  Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.

82  Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept.

81  Highly accurate protein structure prediction with AlphaFold.

80  Highly accurate protein structure prediction for the human proteome.

79  Protein structure modeling enables the rapid solution of protein structures and provides insights into function.

78  Accurate prediction of protein structures and interactions using a three-track neural network.

77  Interferon-induced APOL3 is a detergent-like protein that kills cytosolic pathogens to protect human cells against infection.

76  Data storage using peptide sequences.

75  Computationally designed proteins assemble antibodies into precise and potent nanostructures.

74  The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.

73  The intracellular environment affects protein–protein interactions.

72  A versatile platform reprograms botulinum neurotoxin proteases to selectively cleave proteins of biomedical interest in vitro and in neurons.

71  Successful de novo design of transmembrane β-barrel proteins provides insight into the principles that guide their folding.

70  DeepTFactor: A deep learning-based tool for the prediction of transcription factors.

69  The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease.

68  Structures of the acetohydroxyacid synthase complexes of Saccharomyces cerevisiae and Arabidopsis thaliana provide insights into the biosynthesis of and feedback inhibition by branched-chain amino acids.

67  ROR2 blockade improves the functional and structural outcomes of osteoarthritis in preclinical animal models by inhibiting YAP signaling.

66  In a mouse model of the leukodystrophy Pelizaeus–Merzbacher disease, myelination, motor performance, respiratory function and lifespan are improved by suppressing proteolipid protein expression, suggesting PLP1 as a therapeutic target for human patients with this disease and, more broadly, antisense oligonucleotides as a pharmaceutical modality for treatment of myelin disorders.

65  An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.

64  Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion.

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