17  A distinct abundant group of microbial rhodopsins discovered using functional metagenomics.

16  Efficient encapsulation of proteins with random copolymers.

15  Loss of esophageal SPINK7 unleashes protease activity, impairs barrier function, and induces proinflammatory responses.

14  A knock-in mutation in beclin 1 that increases autophagy in mice extends animal lifespan, improves healthspan, and also rescues early lethality in mice deficient in the anti-ageing protein klotho.

13  Xenoprotein engineering via synthetic libraries.

12  Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

11  The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species.

10  A system that combines nanoscale synthesis and affinity ranking enables high-throughput screening of reaction conditions and bioactivity for a given protein target, accelerating the process of drug discovery.

9  Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics.

8  A bound reaction intermediate sheds light on the mechanism of nitrogenase.

7  Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.

6  Light-activated protein interaction with high spatial subcellular confinement.

5  Optically functional isoxanthopterin crystals in the mirrored eyes of decapod crustaceans.

4  The mechanism by which mitochondrial outer membrane proteins are inserted is elucidated.

3  Phase separation of a yeast prion protein promotes cellular fitness.

2  A Method for the Acute and Rapid Degradation of Endogenous Proteins.

1  C-reactive protein promotes bone destruction in human myeloma through the CD32–p38 MAPK–Twist axis.

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