Pharmacology

Articles:

204 Optimized arylomycins are a new class of Gram-negative antibiotics.
https://www.nature.com/articles/s41586-018-0483-6

203 A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
http://stm.sciencemag.org/content/10/456/eaar3483

202 Suppression of Staphylococcus aureus virulence by a small-molecule compound.
http://www.pnas.org/content/115/31/8003

201 Species-specific activity of antibacterial drug combinations
https://www.nature.com/articles/s41586-018-0278-9

200 A new class of synthetic retinoid antibiotics effective against bacterial persisters.
https://www.nature.com/articles/nature26157

199 Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals.
http://science.sciencemag.org/content/359/6373/314

198 The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms.
http://stm.sciencemag.org/content/10/423/eaan4044

197 A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.
http://science.sciencemag.org/content/358/6368/1332

196 Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
http://www.cell.com/cell/fulltext/S0092-8674(17)31257-6

195 Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
https://www.nature.com/nature/journal/v550/n7677/full/nature24451.html

194 Chemical synthesis yields gram quantities of a scarce compound under study for treating HIV, cancer, and Alzheimer’s disease.
http://science.sciencemag.org/content/358/6360/218

193 Ceftazidime-avibactam has potent sterilizing activity against highly drug-resistant tuberculosis.
http://advances.sciencemag.org/content/3/8/e1701102

192 Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents.
https://www.nature.com/articles/s41467-017-00419-5

191 Plasmonic silver nanoshells for drug and metabolite detection.
https://www.nature.com/articles/s41467-017-00220-4

190 Synergy of synthesis, computation and NMR reveals correct baulamycin structures.
http://www.nature.com/nature/journal/v547/n7664/full/nature23265.html

189 Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
http://www.cell.com/cell/fulltext/S0092-8674(17)30709-2

188 A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.
https://www.nature.com/articles/s41467-017-00049-x

187 Click chemistry enables preclinical evaluation of targeted epigenetic therapies.
http://science.sciencemag.org/content/356/6345/1397

186 Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
http://www.nature.com/nm/journal/v23/n6/abs/nm.4324.html

185 A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
https://www.nature.com/nature/journal/v546/n7658/full/nature22337.html

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