Molecular Biology


501  The retrotransposition of L1 is controlled by functionally diverse genes at the transcriptional or post-transcriptional levels, and its silencing can lead to the downregulation of host gene expression.

500  Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.

499  An RNA-editing technology is developed to efficiently and specifically deplete and correct RNA directly in mammalian cells.

498  Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells.

497  Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology.

496  Origin of the RNA world: The fate of nucleobases in warm little ponds.

495  Switch to Standard View Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.

494  The transcription fidelity factor GreA impedes DNA break repair.

493  An RNA-targeting Cas9 system induces degradation of microsatellite repeat expansion RNAs, highlighting the potential of RNA-targeting CRISPR systems for therapeutic purposes.

492  Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers.

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