Cancer Biology

922 Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.

921 Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.

920 Genotype-targeted local therapy of glioma.

919 Classification of prostate cancer using a protease activity nanosensor library.

918 The gene fusions driving sarcoma growth often arise by the formation of dramatic genomic loops that rearrange many genes.

917 Glucose–insulin feedback can reactivate PI3K in tumours treated with PI3K inhibitors, reducing therapeutic efficacy, but this effect can be reduced by using drugs or diet to suppress the insulin response.

916 KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

915 Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.

914 Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.

913 Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone.

912 LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade.

911 Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

910 Leukaemia hijacks a neural mechanism to invade the central nervous system.

909 Histidine metabolism influences the sensitivity of cancer cells to methotrexate, with mice bearing leukaemia xenografts showing increased response to the drug upon histidine supplementation.

908 Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.

907 A ubiquitin ligase–regulated transcription factor activated in kidney cancer is identified.

906 Prediction of acute myeloid leukaemia risk in healthy individuals.

905 CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors.

904 A designer self-assembled supramolecule amplifies macrophage immune responses against aggressive cancer.

903 Patterns of genomic evolution in advanced melanoma.

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