Cancer Biology

 
880 Chimeric antigen receptor (CAR)-T cells expressing the cytokines IL-7 and CCL19 show improved clearance of established solid tumors in mice.
https://www.nature.com/articles/nbt.4086

879 In chronic myelogenous leukemia, leukemia stem cell function requires a microRNA that is provided by bone marrow endothelial cells.
https://www.nature.com/articles/nm.4499

878 The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding spliceosome components.
https://www.nature.com/articles/nm.4493

877 Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.
https://www.nature.com/articles/nm.4507

876 Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.
https://www.nature.com/articles/s41586-018-0018-1

875 Reassembly of 89Zr‐Labeled Cancer Cell Membranes into Multicompartment Membrane‐Derived Liposomes for PET‐Trackable Tumor‐Targeted Theranostics.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201704934

874 Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity.
http://science.sciencemag.org/content/359/6383/1537

873 The protein histidine phosphatase LHPP is a tumour suppressor.
https://www.nature.com/articles/nature26140

872 Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors.
http://www.pnas.org/content/115/12/E2811

871 DNA methylation-based classification of central nervous system tumours.
https://www.nature.com/articles/nature26000

870 Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases.
http://stm.sciencemag.org/content/10/433/eaar1916

869 In mice, tumor cells can metastasize via lymph node blood vessels.
http://science.sciencemag.org/content/359/6382/1408

868 Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.
http://science.sciencemag.org/content/359/6382/1403

867 A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects.
https://www.nature.com/articles/nm.4478

866 A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
https://www.nature.com/articles/nbt.4071

865 Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.
https://www.nature.com/articles/nature25795

864 The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanisms.
http://jem.rupress.org/content/215/3/911

863 Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity.
http://jem.rupress.org/content/215/3/877

862 A commensal strain of Staphylococcus epidermidis protects against skin neoplasia.
http://advances.sciencemag.org/content/4/2/eaao4502

861 Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.
http://science.sciencemag.org/content/359/6378/920

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