Cancer Biology

945 The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

944 An immunoprecipitation-based protocol is developed to analyse DNA methylation in small quantities of circulating cell-free DNA, and can detect and classify cancers in plasma samples from several tumour types.

943 Autophagy maintains tumour growth through circulating arginine.

942 Enhanced detection of circulating tumor DNA by fragment size analysis.

941 Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.

940 Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer.

939 Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers.

938 Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles.

937 Enhanced Transdermal Drug Delivery by Transfersome-Embedded Oligopeptide Hydrogel for Topical Chemotherapy of Melanoma.

936 Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma.

935 Chromatin accessibility profiling identifies principles of epigenetic regulation in 23 primary human cancers.

934 Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis.

933 Local generation of hydrogen for enhanced photothermal therapy.

932 BAP1 links metabolic regulation of ferroptosis to tumour suppression.

931 Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy.

930 SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.

929 The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells.

928 Prostate and lung cancers convert to a drug-resistant, lethal form of cancer through the same reprogramming mechanism.

927 Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.

926 Necroptosis microenvironment directs lineage commitment in liver cancer.

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