Cancer Biology

 
895 All-in-One Theranostic Nanoagent with Enhanced Reactive Oxygen Species Generation and Modulating Tumor Microenvironment Ability for Effective Tumor Eradication.
https://pubs.acs.org/doi/10.1021/acsnano.8b01893

894 Snail knockdown reverses stemness and inhibits tumour growth in ovarian cancer.
http://www.nature.com/articles/s41598-018-27021-z

893 PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids.
http://www.pnas.org/content/115/22/E5066

892 Cross-talk between bacteria and bile acid promotes natural killer T cell antitumor immunity in the liver.
http://science.sciencemag.org/content/360/6391/eaan5931

891 A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent.
http://stm.sciencemag.org/content/10/442/eaah4807

890 Circular ssDNA can sequester inhibitory microRNAs to restore tumor suppressor gene function, thereby inhibiting tumor progression.
http://stm.sciencemag.org/content/10/442/eaao6321

889 KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
https://www.nature.com/articles/s41586-018-0128-9

888 Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.
https://www.nature.com/articles/s41556-018-0083-6

887 Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis
http://stm.sciencemag.org/content/10/441/eaap8307

886 An online resource maps the molecular genetic features of glioblastoma, a lethal brain cancer, to its anatomic features.
http://science.sciencemag.org/content/360/6389/660

885 Development of a stress response therapy targeting aggressive prostate cancer.
http://stm.sciencemag.org/content/10/439/eaar2036

884 p52 expression enhances lung cancer progression.
https://www.nature.com/articles/s41598-018-24488-8

883 Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.
http://stm.sciencemag.org/content/10/436/eaao5931

882 Dual inhibition of MDMX and MDM2 by an α-helical p53-stapled peptide (ALRN-6924) results in robust antitumor activity in acute myeloid leukemia.
http://stm.sciencemag.org/content/10/436/eaao3003

881 CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy.
https://www.nature.com/articles/s41556-018-0065-8

880 Chimeric antigen receptor (CAR)-T cells expressing the cytokines IL-7 and CCL19 show improved clearance of established solid tumors in mice.
https://www.nature.com/articles/nbt.4086

879 In chronic myelogenous leukemia, leukemia stem cell function requires a microRNA that is provided by bone marrow endothelial cells.
https://www.nature.com/articles/nm.4499

878 The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding spliceosome components.
https://www.nature.com/articles/nm.4493

877 Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.
https://www.nature.com/articles/nm.4507

876 Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.
https://www.nature.com/articles/s41586-018-0018-1

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