Cancer Biology

880 Chimeric antigen receptor (CAR)-T cells expressing the cytokines IL-7 and CCL19 show improved clearance of established solid tumors in mice.

879 In chronic myelogenous leukemia, leukemia stem cell function requires a microRNA that is provided by bone marrow endothelial cells.

878 The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding spliceosome components.

877 Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.

876 Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.

875 Reassembly of 89Zr‐Labeled Cancer Cell Membranes into Multicompartment Membrane‐Derived Liposomes for PET‐Trackable Tumor‐Targeted Theranostics.

874 Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity.

873 The protein histidine phosphatase LHPP is a tumour suppressor.

872 Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors.

871 DNA methylation-based classification of central nervous system tumours.

870 Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases.

869 In mice, tumor cells can metastasize via lymph node blood vessels.

868 Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.

867 A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects.

866 A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.

865 Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.

864 The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanisms.

863 Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity.

862 A commensal strain of Staphylococcus epidermidis protects against skin neoplasia.

861 Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

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