Cancer Biology

784 An immunogenic personal neoantigen vaccine for patients with melanoma.

783 Contrary to expectation, lymphatic and distant metastases often arise independently in human colorectal cancer.

782 Identification of the cell types from which relapse arises in acute myeloid leukaemia, by following leukaemia propagation from patient-derived leukaemia samples.

781 Applying a new, more sensitive single-cell transcriptomics method to diagnosis, remission and progression samples from patients with chronic myeloid leukemia reveals insight into the heterogeneity of cells that resist treatment with targeted therapy, as well as into the dynamics of disease progression and its effects on nontransformed hematopoietic stem cells.

780 Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

779 Genetically engineered ‘lymphoreporter’ mouse strains are used to track melanoma dissemination in vivo, identifying midkine as a tumour-secreted factor that acts at a distance, preparing pre-metastatic niches and serving as an indicator of poor prognosis in patients.

778 Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids.

777 Genetically engineered colon organoids form tumors that undergo a stepwise progression toward metastatic disease after orthotopic transplantation.

776 Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.

775 Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance.

774 argeting BMI1+ Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma.

773 Inactivated vaccinia virus induces antitumor immunity that can overcome resistance to checkpoint inhibitors.

772 Anti-LAP antibody induces antitumor immunity by affecting both adaptive and innate immune mechanisms.

771 The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.

770 Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast, PD-L1 removal increases phagocytosis in vivo, decreases tumour burden and increases survival of mice.

769 Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.

768 VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer.

767 Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

766 A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.

765 Whole-genome landscapes of major melanoma subtypes.

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