Cancer Biology

813 Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities.

812 Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells.

811 Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

810 An anti–glypican 3/CD3 bispecific T cell–redirecting antibody for treatment of solid tumors.

809 Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

808 Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts.

807 Analysis of global remethylation in mouse embryos at several developmental stages identifies an epigenetic landscape that partitions extraembryonic tissues within the embryo and resembles a frequent, global departure in genome regulation in human cancers.

806 Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.

805 Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen–specific CTLs.

804 Tumor-associated B-cells induce tumor heterogeneity and therapy resistance.

803 Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma.

802 Using unique barcodes for tumour cells, the authors explore the dynamics of human glioblastoma subpopulations, and suggest that clonal heterogeneity emerges through stochastic fate decisions of a neutral proliferative hierarchy.

801 Large-scale enhancer reprogramming directed by transcription factors such as FOXA1 drives metastasis in the organoid model of pancreatic cancer.

800 Distinct tumor immune microenvironments co-exist within a single individual and may help to explain the heterogeneous fates of metastatic lesions often observed post-therapy.

799 Molecular machines open cell membranes.

798 Identification of essential genes for cancer immunotherapy.

797 CDK4/6 inhibition triggers anti-tumour immunity.

796 SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis.

795 Ultrastable Near-Infrared Conjugated-Polymer Nanoparticles for Dually Photoactive Tumor Inhibition.

794 Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors.

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