Cancer Biology

867 A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects.

866 A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.

865 Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.

864 The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanisms.

863 Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity.

862 A commensal strain of Staphylococcus epidermidis protects against skin neoplasia.

861 Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

860 Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.

859 Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

858 Renal cell cancers with mutations in a specific chromatin regulator have a better clinical response to immunotherapy.

857 Inactivation of a chromatin remodeling complex in tumor cells enhances their sensitivity to killing by T cells.

856 Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.

855 Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.

854 A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.

853 Targeting IRF3 as a YAP agonist therapy against gastric cancer.

852 Asparagine bioavailability governs metastasis in a model of breast cancer.

851 Targeting of p53- and PUMA-dependent apoptosis protects intestinal stem cells, but not cancer cells, against chemotherapy.

850 HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

849 Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.

848 Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy.

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