228  The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis.

227  Using a make-on-demand library that contains hundreds-of-millions of molecules, structure-based docking was used to identify compounds that, after synthesis and testing, are shown to interact with AmpC β-lactamase and the D4 dopamine receptor with high affinity.

226  Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

225  Two-step pathway for isoprenoid synthesis.

224  Dietary sugar silences a colonization factor in a mammalian gut symbiont.

223  Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.

222  A metal-binding peptide becomes a potent catalyst for ester hydrolysis.

221  Mannose impairs tumour growth and enhances chemotherapy.

220  A biomimetic receptor for glucose.

219  Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model.

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